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SEMO Football 2021 Schedule
| September 2nd (Thursday) | 6:30 PM | vs Southern Illinois |
| September 11th (Saturday) | 6:00 PM | @ Sam Houston |
| September 18th (Saturday) | 11:00 AM | @ Missouri |
| September 25th (Saturday) | 2:00 PM | vs Tennessee State |
| October 2nd (Saturday) | 1:30 PM | @ Tennessee Tech |
| October 9th (Saturday) | 3:00 PM | @ Austin Peay |
| October 16th (Saturday) | 2:00 PM | vs Murray State |
| October 23rd (Saturday) | 2:00 PM | @ UT Martin |
| October 30th (Saturday) | 1:00 PM | vs Eastern Illinois |
| November 13th (Saturday) | 1:00 PM | @ Murray State |
| November 20th (Saturday) | 1:00 PM | vs UT Martin |